仪军玲¹  李彩霞²  胡 兰²

（1.中国人民公安大学，100038；2.公安部物证鉴定中心，100038）

【摘 要】 单核苷酸多态性(single nucleotide polymorphisms，SNPs)，作为第三代遗传标记，已经广泛应用于基因作图、遗传性和遗传相关性疾病的诊断、群体遗传学、药学研究和法医学等领域。SNP 的检测方法多种多样，本文简要介绍SNP的特点和几种检测方法。

【关键词】 单核苷酸多态性；SNP；检测方法

【中图分类号】 D919.2

【文献标识码】 A

【文章编号】 1674-1226（2008）06-0757-07

Single Nucleotide Polymorphisms And Detection Approaches. Yi Junling. Chinese People′s Public Security University, Beijing 100038

【Abstract】 As the third generation of genetic marker SNPs (Single nucleotide polymorphisms) has been widely used in genetic mapping, diagnosis of genetic and gene-related diseases, population genetics, pharmaceutical research and forensic science. There are multiple SNPs detection approaches. In this report we describe the SNPs characteristics and several detection methods.

【Key words】 Single nucleotide polymorphism，SNP，Detection approach